![Opioid system is necessary but not sufficient for antidepressive actions of ketamine in rodents | PNAS Opioid system is necessary but not sufficient for antidepressive actions of ketamine in rodents | PNAS](https://www.pnas.org/cms/10.1073/pnas.1916570117/asset/c03e80f7-e96c-4e06-ae36-52c2c4fe7006/assets/graphic/pnas.1916570117fig01.jpeg)
Opioid system is necessary but not sufficient for antidepressive actions of ketamine in rodents | PNAS
![Protracted Effects of Ketamine Require Immediate Kappa Opioid Receptor Activation and Long‐Lasting Desensitization - Jacobson - 2020 - The FASEB Journal - Wiley Online Library Protracted Effects of Ketamine Require Immediate Kappa Opioid Receptor Activation and Long‐Lasting Desensitization - Jacobson - 2020 - The FASEB Journal - Wiley Online Library](https://faseb.onlinelibrary.wiley.com/cms/asset/9127bdd8-0ec3-4aab-bbaf-7a2fd1245beb/fsb2.v34.s1.cover.jpg?trick=1673188434391)
Protracted Effects of Ketamine Require Immediate Kappa Opioid Receptor Activation and Long‐Lasting Desensitization - Jacobson - 2020 - The FASEB Journal - Wiley Online Library
![Constitutive activation of kappa opioid receptors at ventral tegmental area inhibitory synapses following acute stress | eLife Constitutive activation of kappa opioid receptors at ventral tegmental area inhibitory synapses following acute stress | eLife](https://iiif.elifesciences.org/lax/23785%2Felife-23785-fig7-v1.tif/full/,1500/0/default.jpg)
Constitutive activation of kappa opioid receptors at ventral tegmental area inhibitory synapses following acute stress | eLife
![The Role of Dynorphin and the Kappa Opioid Receptor in the Symptomatology of Schizophrenia: A Review of the Evidence - ScienceDirect The Role of Dynorphin and the Kappa Opioid Receptor in the Symptomatology of Schizophrenia: A Review of the Evidence - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0006322319313794-gr1.jpg)
The Role of Dynorphin and the Kappa Opioid Receptor in the Symptomatology of Schizophrenia: A Review of the Evidence - ScienceDirect
![Frontiers | Dynorphin/kappa opioid receptor system regulation on amygdaloid circuitry: Implications for neuropsychiatric disorders Frontiers | Dynorphin/kappa opioid receptor system regulation on amygdaloid circuitry: Implications for neuropsychiatric disorders](https://www.frontiersin.org/files/MyHome%20Article%20Library/963691/963691_Thumb_400.jpg)
Frontiers | Dynorphin/kappa opioid receptor system regulation on amygdaloid circuitry: Implications for neuropsychiatric disorders
![Chronic Kappa opioid receptor activation modulates NR2B: Implication in treatment resistant depression | Scientific Reports Chronic Kappa opioid receptor activation modulates NR2B: Implication in treatment resistant depression | Scientific Reports](https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fsrep33401/MediaObjects/41598_2016_Article_BFsrep33401_Fig1_HTML.jpg)
Chronic Kappa opioid receptor activation modulates NR2B: Implication in treatment resistant depression | Scientific Reports
![Pharmacological and behavioral divergence of ketamine enantiomers: implications for abuse liability | Molecular Psychiatry Pharmacological and behavioral divergence of ketamine enantiomers: implications for abuse liability | Molecular Psychiatry](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41380-021-01093-2/MediaObjects/41380_2021_1093_Fig1_HTML.png)
Pharmacological and behavioral divergence of ketamine enantiomers: implications for abuse liability | Molecular Psychiatry
![Ketamine: Promising Path or False Prophecy in the Development of Novel Therapeutics for Mood Disorders? | Neuropsychopharmacology Ketamine: Promising Path or False Prophecy in the Development of Novel Therapeutics for Mood Disorders? | Neuropsychopharmacology](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fnpp.2014.261/MediaObjects/41386_2015_Article_BFnpp2014261_Fig1_HTML.jpg)
Ketamine: Promising Path or False Prophecy in the Development of Novel Therapeutics for Mood Disorders? | Neuropsychopharmacology
![Rapid‐acting antidepressant ketamine, its metabolites and other candidates: A historical overview and future perspective - Hashimoto - 2019 - Psychiatry and Clinical Neurosciences - Wiley Online Library Rapid‐acting antidepressant ketamine, its metabolites and other candidates: A historical overview and future perspective - Hashimoto - 2019 - Psychiatry and Clinical Neurosciences - Wiley Online Library](https://onlinelibrary.wiley.com/cms/asset/f19b2dee-7120-47b8-b454-e4643e6fde19/pcn12902-fig-0003-m.jpg)
Rapid‐acting antidepressant ketamine, its metabolites and other candidates: A historical overview and future perspective - Hashimoto - 2019 - Psychiatry and Clinical Neurosciences - Wiley Online Library
![Ketamine Metabolite (2R,6R)-Hydroxynorketamine Interacts with μ and κ Opioid Receptors | ACS Chemical Neuroscience Ketamine Metabolite (2R,6R)-Hydroxynorketamine Interacts with μ and κ Opioid Receptors | ACS Chemical Neuroscience](https://pubs.acs.org/cms/10.1021/acschemneuro.0c00741/asset/images/large/cn0c00741_0001.jpeg)
Ketamine Metabolite (2R,6R)-Hydroxynorketamine Interacts with μ and κ Opioid Receptors | ACS Chemical Neuroscience
![Frontiers | Novel Insights Into the Neurobiology of the Antidepressant Response From Ketamine Research: A Mini Review Frontiers | Novel Insights Into the Neurobiology of the Antidepressant Response From Ketamine Research: A Mini Review](https://www.frontiersin.org/files/MyHome%20Article%20Library/759466/759466_Thumb_400.jpg)
Frontiers | Novel Insights Into the Neurobiology of the Antidepressant Response From Ketamine Research: A Mini Review
![Ketamine Metabolite (2R,6R)-Hydroxynorketamine Interacts with μ and κ Opioid Receptors | ACS Chemical Neuroscience Ketamine Metabolite (2R,6R)-Hydroxynorketamine Interacts with μ and κ Opioid Receptors | ACS Chemical Neuroscience](https://pubs.acs.org/cms/10.1021/acschemneuro.0c00741/asset/images/large/cn0c00741_0004.jpeg)
Ketamine Metabolite (2R,6R)-Hydroxynorketamine Interacts with μ and κ Opioid Receptors | ACS Chemical Neuroscience
![Attenuation of Antidepressant Effects of Ketamine by Opioid Receptor Antagonism | American Journal of Psychiatry Attenuation of Antidepressant Effects of Ketamine by Opioid Receptor Antagonism | American Journal of Psychiatry](https://ajp.psychiatryonline.org/cms/10.1176/appi.ajp.2018.18020138/asset/images/medium/appi.ajp.2018.18020138f2.gif)
Attenuation of Antidepressant Effects of Ketamine by Opioid Receptor Antagonism | American Journal of Psychiatry
![Ketamine Metabolite (2R,6R)-Hydroxynorketamine Interacts with μ and κ Opioid Receptors | ACS Chemical Neuroscience Ketamine Metabolite (2R,6R)-Hydroxynorketamine Interacts with μ and κ Opioid Receptors | ACS Chemical Neuroscience](https://pubs.acs.org/cms/10.1021/acschemneuro.0c00741/asset/images/large/cn0c00741_0002.jpeg)